Ep. 322: “Healing Hearts with Macrophages” Featuring Dr. Filipa Simões

Dr. Filipa Simões is a Group Leader at the University of Oxford and Co-Director of the Oxford Organoid Hub. She discusses how macrophages shape heart development, repair, and regeneration, and how cellular crosstalk within the cardiac niche influences tissue outcomes after injury. Using zebrafish models, stem cell–derived cardiac organoids, and spatial genomics approaches, she explores the molecular signals that govern macrophage identity and function, with the goal of uncovering new strategies to promote cardiac regeneration and limit fibrosis.