TWiM #107: The battle in your bladder

Hosts: Vincent Racaniello and Michael Schmidt.

Vincent and Michael discuss the highly diverse microbiome of uncontacted Amerindians, and how the composition of human urine plays a role in the battle for iron.

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• Microbiome of uncontacted Amerindians (Sci Adv)
• Urinary composition controls siderocalin activity (J Biol Chem)
• Urine acidity and UTI susceptibility (Infect Cont Today)
• Image (from pdb file 3cmp) shows siderocalin (magenta) complexed
• with iron (orange) and enterobactin (sticks)

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