TWiV 1373: Challenging Dengue and RIGging Flu

TWiV explains results of a dengue virus human challenge which reveals that preexisting immunity shapes viral replication and broadly protective responses, and how influenza virus antagonizes self-sensing by RIG-I to enhance viral replication.

Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker

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Links for this episode

• Support science education at MicrobeTV
• Democratic doctors win big in 2026 midterm elections (CIDRAP)
• Florida’s dengue total jumps to 485 (CIDRAP)
• Dengue virus human challenge study (Sci Transl Med)
• Influenza virus and self sensing of host by RIG-I (Cell Rep)
• Letters read on TWiV 1373
• Timestamps by Jolene Ramsey. Thanks!

Picks of the Week

Brianne – Five Science-Backed Benefits of ‘grandma hobbies’ Kathy – Bird of the Week from Ben Tonelli Alan – The Dark Frontier, by Jeffrey Marlow Vincent – Where Do Photons Actually Go When You Turn Off The Light?

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Content in this podcast should not be construed as medical advice.