A New Era In Alzheimer's Research with Sarah DeVos
Om avsnittet
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On this episode of Translating Proteomics, host Andreas Huhmer discusses advances in Alzheimer’s research with special guest and Curie Bio Drug Maker in Residence, Sarah DeVos Ph.D. Their conversation focuses on:
- The impact of molecular diagnostics on Alzheimer’s research
- Recent Alzheimer’s drug approvals
- The future of Alzheimer’s research
*Small edit on Sarah's background - She did her graduate work at Washington University in St. Louis and a Postdoc at Massachusetts General Hospital*
Chapters
00:00 – Introduction
01:54 – Why Sarah began studying Alzheimer’s
03:39 – Current tools and needs for future Alzheimer’s diagnostics
09:52 – Recent drug approvals in the Alzheimer’s space and their relationship to diagnostics
14:26 – Is it possible to develop biomarkers that detect Alzheimer’s at its earliest stages?
16:36 – What is limiting the development of new Alzheimer’s biomarkers?
17:51 – The DIAN trials and learnings from studying dominantly inherited Alzheimer’s
19:33 – The genetics of Alzheimer’s
22:19 – Novel approaches to identifying and understanding Alzheimer’s pathology
25:54 – Where can proteomics advance Alzheimer’s research?
31:25 – The role of proteomics in Alzheimer’s animal models
34:33 – Sarah’s hopes for the next 10 years of Alzheimer’s research
41:39 - Outro
Resources
Dominant Inherited Alzheimer’s Network (DIAN) trials research updates
o In the DIAN trials, researchers work with families to study various clinical and basic science aspects of dominantly inherited Alzheimer’s disease.
Amyloid plaque reducing clinical trials:
o Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer's Disease (Haeberlein et al. 2022)
o Lecanemab in Early Alzheimer’s Disease (Van Duck et al. 2022)
o Clinical research into a new phospo-tau biomarker that can help physicians more effectively diagnose Alzheimer’s disease
Resurrecting the Mysteries of Big Tau (Fischer and Baas 2021)
o Review covering a potentially neuro-protective form of tau called “Big tau”
o Paper linking the NRN1 protein to cognitive resilience in Alzheimer’s
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