Why American Investors Should Have a Pulse on China with James Wang

In this episode of Differentiated Understanding, I talk with James Wang, general partner at deep-tech fund Creative Ventures, author of What You Need to Know About AI: A Primer on Being Human in an Artificially Intelligent World, and writer of the newsletter Weighty Thoughts. James has sat on nearly every side of the table — Bridgewater investor, startup founder/CTO in healthcare, engineer at Google — and now backs “real-world AI” from semiconductors and interconnects to diagnostics and industrial systems.

We start with how the AI investing landscape has evolved since 2016: why “AI” used to be a dirty word in pitch decks, how the post–ChatGPT boom funneled capital into a small set of model companies, and why so many AI startups shot up to tens of millions in ARR only to fall back as incumbents absorbed their features. James explains where he still sees real opportunity — especially in vertical AI built on hard-to-replicate proprietary data — and why moats in healthcare and industrial AI look very different from the “GPT wrapper” era.

From there, we zoom out. We compare China vs. the US on AI pragmatism, industrial policy, and consumer vs. enterprise strengths; unpack the open-source vs. closed-source model debate; and talk about how agentic AI is already furthest along in developer tools. James also breaks down the energy reality of AI: why GPUs turn power into intelligence, how much additional load AI really adds to the grid, and what the Inflation Reduction Act and its partial rollback actually changed (and didn’t) for data centers and renewables.

We close with James’s differentiated view: that over time, AI’s gains will be largely socialized — diffused into everyday life via cheap, ubiquitous models (often running at the edge) rather than captured as persistent monopoly profits by a tiny set of firms.

In today’s world, there’s no shortage of information. Knowledge is abundant, perspectives are everywhere. But true insight doesn’t come from access alone—it comes from differentiated understanding. It’s the ability to piece together scattered signals, cut through the noise and clutter, and form a clear, original perspective on a situation, a trend, a business, or a person. That’s what makes understanding powerful.

Every episode, I bring in a guest with a unique point of view on a critical matter, phenomenon, or business trend—someone who can help us see things differently.

For more information on the podcast series, see here.

Topics we covered:

* What “real-world AI” means: interconnects, power, semis, diagnostics, industrial systems

* How AI investing has changed from “don’t say AI” to “everyone is an AI startup”

* Why many high-flying AI startups lacked moats and saw revenue fall back to earth

* The case for vertical AI built on scarce, proprietary data (e.g., medical imaging, acoustics)

* China’s strength in industrial AI and consumer apps vs. the US edge in enterprise SaaS

* Open-source vs. closed-source models, and what really matters for enterprise buyers

* What “agentic AI” actually is, and why dev tools are still the most advanced real use case

* AI’s power appetite, data centers going “behind the meter,” and the limits of US grid politics

* Why James believes most of AI’s value will show up in broad productivity gains, not just in a few mega-caps

AI-generated transcipt

Grace Shao (00:01)

Hey everyone, welcome back to another episode of Differential Understanding. Today, joining me is James Wong. James is a general partner at Creative Ventures, spearheading investments in AI across the stack. He was previously the co-founder and CTO of Lioness Health, and before that he was on the core investment team at Bridgewater Associates. He founded a nonprofit consulting firm specializing in microfinance and had a short stint at Google. I’m very excited to actually have you on today, James.

James Wang (00:33)

Super excited to be here too. Thanks so much, Grace.

Grace Shao (00:36)

James, it’s really great to actually finally meet you, I guess, in person. We were just kind of laughing about this. We’ve talked on and off on Substack on WhatsApp, on email for quite a while now. I’ve been a really big fan of your writing and you are actually one of the first paid, I think, subscribers to my own newsletter, AI Proem as well. So for listeners, his newsletter is called Weighty Thoughts. He writes everything about the startup space, VC, AI, know, FinTech, I think, and know, bigger pictures as well, right? But ⁓ start with James, why don’t you tell us about your day job? What is it that you do when you say you invest in AI? What are you investing in? And what kind of businesses are you looking at these days?

James Wang (01:19)

Yeah, sounds great. yeah, glad to be one of the early subscribers to AI Proem because yeah, as a VC, you have to catch the good thing early. it’s a part of the job there. Yeah. So Creative Ventures is an early stage deep tech fund. So deep tech has gone through quite a few evolutions in terms of what it is or isn’t to people.

For us, it is things with harder science and IP barriers. So that includes things like battery manufacturing platforms that cost a billion dollars a piece, AI diagnostics that are completely end to end with no clinicians in the loop, things like materials discovery platforms using AI. So a lot of these different areas that have gotten pretty exciting with AI as well. think one of the interesting things is deep tech, especially within say like some of the materials discovery spaces, the bio space, like a lot of these areas have accelerated quite a bit with AI’s ⁓ involvement at this point. And there’s a lot of exciting things coming up in those areas.

Grace Shao (02:27)

I think you know beyond a business background which a lot of investors have you actually have a technical background as well ⁓ What do you think that like does that make you? More understanding of the deep tech that you’re looking into or do you have any unique perspective on technology companies when you look at investing in them?

James Wang (02:47)

Yeah, totally. So for us, for our team, actually, I’m one of the few folks without a PhD. So a of the team does actually have that kind of background, which is needed within deep tech ⁓ in large part because it’s you do need to understand how the technology works in order to understand the market that it goes into. That being said, like like most technology startups, the ultimate challenge is finding the right market and scaling.

But if you don’t understand the technology on a base level in terms of what it does, it’s really, really hard to actually figure out how to scale the thing. So a lot of that technical background, especially within these areas is quite critical. And I guess just my opinion as well, like a lot of different asset management areas undergo evolution. VC historically has been one that has allowed a lot of generalism within it just because of the nature of how a lot of the software boom went came up and went through and everything. But our opinion is actually a lot of the investors in this particular area will get more and more niche, especially with AI, which I think we might jump into as well. AI does actually involve and help enable a lot of vertically integrated industries ⁓ in interesting ways, which means that, you end up with investors who get more and more specialized in their areas.

Grace Shao (04:00)

Mm-hmm. How big are these ticket sizes that we’re talking about when you’re investing in and how early are you looking at?

James Wang (04:13)

Yeah, typically speaking for us, we are often the first institutional investor in that being said, some of our companies have five, 10, even like 20 million dollars in non dilutive government grant funding or research funding before we actually invest. So it’s kind of hard to say when you’re trying to pin that down. That being said, yeah, we’re among the first investors in. Usually we invest around a million in terms of initial check size and sort of ramp from there.

Grace Shao (04:28)

I see.

James Wang (04:42)

…

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