March 2025: The Impact of Xanomeline and Trospium Chloride on Cognitive Impairment in Acute Schizophrenia: Replication in Pooled Data From Two Phase 3 Trials

Dr. William Horan (Bristol Myers Squibb) joins AJP Audio to discuss a newly approved, novel treatment for schizophrenia spectrum disorder, which has potential impacts for cognition in patients. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the March issue into context.

• 00:45 Horan interview
• 03:15 Novel mechanism of action in the treatment of schizophrenia
• 05:39 Side effect profiles
• 07:20 Clinical impacts
• 08:31 The need for further investigation
• 09:58 Limitations
• 11:05 Further research
• 13:08 Kalin interview
• 13:21 Horan et al.
• 17:34 Levenstein et al.
• 19:00 Fountoulakis et al.
• 20:57 Couture et al.
• 23:18 Stern et al.
• 27:35 McGirr et al.

Transcript

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