076-Bone metastases diminish extraosseous response to ICB

This article explores how bone metastases can hinder the effectiveness of immune checkpoint blockade (ICB) therapies in tumors located elsewhere in the body. The research highlights that osteoclasts, cells involved in bone breakdown, are conditioned by bone tumors to produce osteopontin (OPN), a protein that circulates and suppresses anti-tumor T cells in primary tumors. The study demonstrates tha...去小宇宙查看完整单集简介
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