077-Single-cell epigenomic rewiring in Alzheimer’s disease

This article explores the epigenomic and transcriptomic changes in Alzheimer's disease (AD) progression and cognitive resilience, utilizing single-cell multi-region analysis across six brain areas. The authors reveal widespread epigenomic relaxation and information loss in AD, particularly in vulnerable neurons and exhausted glial cells. Conversely, preserved epigenomic stability is shown to corre...去小宇宙查看完整单集简介
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