101-Computational Design of Specific DNA-Binding Proteins

This article details a novel computational method for designing sequence-specific DNA-binding proteins (DBPs), which are crucial tools in biotechnology and gene editing. The researchers developed a pipeline, incorporating tools like RIFdock and LigandMPNN, to generate small DBPs that can recognize arbitrary DNA sequences, a challenge unmet by previous computational redesign efforts. Experimental v...去小宇宙查看完整单集简介
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