1014-KIRHub: Comprehensive Profiling of Kinase Inhibitors

This study presents a comprehensive biochemical profile of 92 clinical kinase inhibitors—86 of which are FDA-approved—tested against a panel of 758 kinases. By examining 409 wild-type and 349 oncogenic variants, the researchers expanded the known landscape of druggable kinases from 89 to 235. The results reveal significant polypharmacology, demonstrating that most approved drugs inhibit additional...去小宇宙查看完整单集简介
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