1020-p53 Preservation Safeguards Chemical Reprogramming

This research identifies the tumor suppressor p53 as an indispensable driver of human chemical reprogramming, reversing its known role as a barrier in traditional transcription factor-based methods. While suppressing p53 helps create stem cells using the Yamanaka factors, doing so in chemical reprogramming leads to excessive EMT and prevents cells from reaching a pluripotent state. Small molecules...去小宇宙查看完整单集简介
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