1024-GATOR1 Complex role in MYC-Driven Lymphomagenesis

Researchers utilized an in vivo CRISPR/Cas9 genome-wide screen to identify genes that prevent the development of Myc-driven lymphoma. The study discovered that the GATOR1 complex, consisting of the proteins NPRL3, DEPDC5, and NPRL2, acts as a critical tumor suppressor by regulating the mTORC1 signaling pathway. Deleting any of these components significantly accelerates cancer growth in mice, match...去小宇宙查看完整单集简介
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