1028-VIS-seq: Multidimensional Mapping of Variant Effects

This study introduces variant in situ sequencing (VIS-seq), a high-scale platform designed to map how genetic mutations alter the physical and functional characteristics of human cells. By combining pooled protein variant libraries with high-content fluorescent imaging, the method connects specific genotypes to complex cellular phenotypes, such as protein localization and organelle shape. Research...去小宇宙查看完整单集简介
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