1035-Whole-Genome Doubling Drives Immune Evasion

This research reveals how whole-genome doubling (WGD) acts as a primary catalyst for immune evasion in breast cancer. By utilizing mouse models and clinical data, the authors demonstrate that WGD+ tumors transition from an early immunogenic state to a "cold" environment characterized by diminished antigen presentation. This suppression is driven by metabolic shifts, specifically increased succinat...去小宇宙查看完整单集简介
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