1049-LSC Subtypes Driving Venetoclax Resistance in AML

This research identifies four distinct subtypes of leukemic stem cells (LSCs) in acute myeloid leukemia that dictate how patients respond to the drug venetoclax. By profiling over 150 patients, the authors discovered that resistance often stems from LSC plasticity, where cells shift into a megakaryocytic/erythroid state or exist as a rare LAMP5+ monocytic/dendritic (MoDe) subtype. These specific c...去小宇宙查看完整单集简介
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