111-p53 Suppresses Chromatin Noise and Cellular Plasticity

This paper details research into the mechanisms governing cellular plasticity in thymic epithelial cells (mTECs), which is essential for immune tolerance. The authors demonstrate that fluctuations in background chromatin accessibility, termed "epigenetic noise," are amplified during mTEC maturation and promote the ectopic expression of genes normally restricted to other cell types. Crucially, this...去小宇宙查看完整单集简介
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