185-OTX2 Regulation of Splicing in Medulloblastoma

This article investigates the molecular mechanisms driving Group 3 medulloblastoma (MB), an aggressive pediatric brain tumor. It establishes a noncanonical role for the transcription factor OTX2 in regulating alternative splicing, which is crucial for maintaining the tumor's stem cell state. Specifically, the study demonstrates that OTX2 interacts with the large assembly of splicing regulators (LA...去小宇宙查看完整单集简介
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