217-HMGN1 Dosage Drives Down Syndrome Cardiac Defects

This article presents research identifying a key genetic contributor to congenital heart defects (CHDs) associated with Down syndrome, or trisomy 21. Using human induced pluripotent stem cells (hiPSCs) and a mouse model of Down syndrome, the authors investigated dosage-sensitive genes on chromosome 21 that disrupt heart development, specifically focusing on the atrioventricular canal (AVC) defects...去小宇宙查看完整单集简介
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