269-MAGE: Generative AI for De Novo Antibody Design

The article details the generation of antigen-specific paired-chain antibodies using large language models (LLMs). The authors, Wasdin et al., introduce MAGE (monoclonal antibody generator), a sequence-based protein language model fine-tuned to efficiently design diverse human variable heavy- and light-chain antibody sequences targeting specific pathogens. MAGE utilizes an extensive antibody-antig...去小宇宙查看完整单集简介
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