272-OTX2 Governs Human Early Embryonic Genome Activation

The article details the critical role of the maternal transcription factor OTX2 in regulating the initiation of life through human embryonic genome activation (EGA). The research demonstrates that OTX2 is essential for minor EGA at the four-cell stage, promoting the activation of key genes like TPRX1 and TPRX2 and increasing chromatin accessibility by binding to repetitive elements like Alu and Ma...去小宇宙查看完整单集简介
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