276-Compressed Perturb-seq for Genetic Screens

The article introduces a novel, cost-effective method called "compressed Perturb-seq" for large-scale genetic screening of regulatory circuits. This technique modifies the conventional Perturb-seq method by employing algorithmic compressed sensing principles, allowing for measurement of random combinations of genetic perturbations (either through "cell-pooling" or "guide-pooling") and subsequent c...去小宇宙查看完整单集简介
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