287-scArches: Reference Mapping for Single-Cell Atlases

The paper introduces scArches, a novel deep learning strategy based on transfer learning (TL) and architectural surgery, designed for efficiently mapping new, or query, single-cell datasets onto existing, large-scale reference atlases. This method addresses the challenges in single-cell genomics of batch effects between datasets, limited computational resources, and data sharing restrictions by on...去小宇宙查看完整单集简介
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