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Paper Talk

296-PRISM: Single-Round High-Multiplex Spatial RNA Imaging

15 min5 december 2025
The paper introduces PRISM (profiling of RNA in situ through single-round imaging), a new high-multiplex fluorescent in situ hybridization (FISH) method designed to make spatial RNA imaging more accessible and efficient by overcoming the limitations of conventional microscopy. PRISM expands coding capacity by using color-intensity barcoding within a single round of staining, allowing for up to 64-...去小宇宙查看完整单集简介
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