312-Hypoxia Shifts Melanoma Ferroptosis Reliance to FSP1

The research examines the adaptations utilized by metastatic melanoma cells in the specialized lymph node microenvironment, revealing a vulnerability in their ferroptosis defense system. The hypoxic conditions found in the LNs trigger the breakdown of the primary anti-ferroptosis enzyme, glutathione peroxidase 4 (GPX4), via ubiquitin-proteasome degradation. This loss of GPX4 dependence forces the ...去小宇宙查看完整单集简介
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