313-Whole Genome Doubling Remodels Ovarian Cancer Evolution

This research utilizes single-cell whole-genome sequencing (scWGS) and a novel evolutionary timing method, doubleTime, to characterize the impact of Whole-Genome Doubling (WGD) in high-grade serous ovarian cancer (HGSOC) across 41 patients. The analysis confirmed WGD as a pervasive and ongoing mutational process that greatly increases cell-to-cell diversity and chromosomal instability within tumor...去小宇宙查看完整单集简介
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