321-Hepatic Zonation Dictates Cancer Initiation

This research article explores the non-uniform susceptibility of the liver to cancer, demonstrating that the origin of hepatocellular carcinoma (HCC) is dependent on metabolic zonation. Using mouse models with common HCC driver mutations (Ctnnb1 and Arid2), the authors found that pre-malignant cell clones persisted in Zone 1 but shrank in Zone 3, yet tumors developed far more frequently in Zone 3....去小宇宙查看完整单集简介
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