323-Gq-Biased CCKBR Agonism for Alzheimer's Therapy

The article details a structural and pharmacological approach to treating Alzheimer’s disease (AD) by targeting the cholecystokinin B receptor (CCKBR), a G protein-coupled receptor crucial for memory and learning. The authors used cryo-electron microscopy to visualize the CCKBR complex bound to various G protein subtypes (Gq, Gs, and Gi), establishing that distinct receptor conformations are respo...去小宇宙查看完整单集简介
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