330-COAST: Image-Guided Multi-Modal Spatial Tissue Alignment

The paper introduces COAST (Consecutive multi-Omics Alignment of Spatial Tissues), a novel computational method for accurately aligning consecutive tissue sections analyzed by different spatial omics technologies. COAST exclusively utilizes paired staining images (like H&E or nuclear stains) to create a shared feature space for alignment, eliminating the need for matching molecular profiles or pri...去小宇宙查看完整单集简介
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