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Paper Talk

335-TSC tunes Cortical Progenitor Balance and Neurogenesis

17 min24 december 2025
The study details how the Tuberous Sclerosis Complex (TSC) proteins regulate the balance of progenitor cells, specifically radial progenitors (RG) and intermediate progenitors (IPs), during neocortex development. The research, primarily using mouse models (TSC1/2 cKO), demonstrates that the loss of TSC proteins shifts this balance toward an increase in IPs, leading to the overproduction and aberra...去小宇宙查看完整单集简介
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