340-Hepcidin-Iron Axis Impairs Antiviral Immunity

The article details a study on the pathogenesis of systemic rotavirus (RV) infection and biliary atresia (BA) in neonates, highlighting a critical role for the hepcidin-iron axis. The authors, Xu et al., explain that RV infection triggers persistent Type I Interferon (IFN-I) signaling, which upregulates hepcidin in liver macrophages (specifically TREM2+ macrophages) and hepatocytes. This dysregula...去小宇宙查看完整单集简介
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