344-ApoE Variants Protect Neurons by Oxidized Lipid Efflux

This article presents research demonstrating that protective Apolipoprotein E (ApoE) variants, specifically ApoE2 and ApoE3 Christchurch, support neuronal health by actively effluxing oxidized phospholipids from neurons, a process mediated by the ABCA7 transporter. This mechanism reduces the toxic burden of oxidized lipids, thereby rescuing lysosomal function and protecting neurons from a form of ...去小宇宙查看完整单集简介
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