348-mTORC2 Recognizes AGC Kinases by Long-Range Docking

This article focuses on mTORC2, a protein kinase complex critical for diverse cellular functions, including growth, metabolism, and proliferation, whose dysregulation is implicated in various diseases like cancer. The authors aimed to determine the structural basis for how mTORC2 selectively recognizes and phosphorylates its substrates, particularly Akt, a crucial signaling protein. Using a combin...去小宇宙查看完整单集简介
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