357-SOX2-Driven Niche Sculpts Neutrophil Immunosuppression

This research identifies how SOX2-high tumor-initiating stem cells (tSCs) survive immunotherapy by manipulating the immune environment to create a protective niche. While immunotherapy typically uses interferons to reprogram tumor-associated neutrophils (TANs) into anti-tumor agents, tSCs at the tumor-stroma interface block this transition. The study reveals that these stem cells utilize a SOX2-FA...去小宇宙查看完整单集简介
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