403-EcDNA Variants Drive Oncogenic Transcript Amplification

This research explores how extrachromosomal DNA (ecDNA) functions as a primary catalyst for gene fusions and oncogene amplification in various human cancers. The study identifies that ecDNA-borne fusions, particularly those involving the PVT1 lncRNA, significantly enhance the stability of oncogenic transcripts like MYC. Mechanistically, the PVT1 exon 1 segment binds to the protein SRSF1, allowing ...去小宇宙查看完整单集简介
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