413-DNA Degradation by Ubiquitination Regulates cGAS–STING

This research explores how prostate cancer cells avoid detection by the immune system through the manipulation of the cGAS-STING pathway. Scientists found that SPOP mutations prevent the buildup of DNA in the cell’s cytoplasm, which normally triggers an immune response after radiation damage. Specifically, SPOP usually tags the enzyme TREX1 for destruction, but when mutated, TREX1 levels rise and ...去小宇宙查看完整单集简介
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