414-IGLL5+ B Cells Disrupt TLS Homeostasis and Response

Researchers have identified a specific IGLL5+ B cell subset that drives resistance to immunotherapy in bladder cancer by undermining the integrity of tertiary lymphoid structures (TLSs). These specialized B cells preferentially anchor to high endothelial venules (HEVs), where the IGLL5 protein acts as an inhibitory ligand for the LTβR receptor. This interaction triggers a conformational change tha...去小宇宙查看完整单集简介
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