425-Extracellular GPX4 impairs antitumor immunity

This research identifies GPX4 as a critical immunosuppressive factor released during ferroptosis, a specific type of iron-dependent cell death. While many forms of cell death trigger immune responses, ferroptotic cells often fail to activate robust defenses because extracellular GPX4 binds to the ZP3 receptor on dendritic cells. This interaction triggers a cAMP-PRKA signaling pathway that inhibits...去小宇宙查看完整单集简介
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