430-Cas12a3 cleaves tRNA tails to execute bacterial immunity

This research explores a newly discovered bacterial defense mechanism where the CRISPR–Cas12a3 system provides immunity by specifically targeting and cleaving tRNA tails. While many immune systems disable viral replication by destroying viral genomes, this variant is unique because it preferentially inactivates host tRNAs after recognizing a viral target. By removing the essential 3′ CCA tail of t...去小宇宙查看完整单集简介
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