464-ADAM12: A new Checkpoint impeding Anti-Tumor Immunity

This research identifies ADAM12 as a critical molecular checkpoint in cancer-associated fibroblasts (CAFs) that actively prevents the immune system from attacking tumors. Using advanced CRISPR-based single-cell screening on patient tissues, scientists discovered that ADAM12 maintains a pro-tumor environment by fueling TGF-β signaling and suppressing beneficial interferon responses. When ADAM12 is ...去小宇宙查看完整单集简介
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