476-Hypermutation Patterns in Glioma Tumorigenesis

This research article examines how primary mismatch-repair-deficient high-grade gliomas are categorized into three distinct molecular subgroups based on specific secondary mutations. The study identifies that genomic instability mechanisms dictate whether a tumor develops through point mutations or copy number alterations, creating an inverse relationship between these two genetic events. Notably,...去小宇宙查看完整单集简介
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