488-Neddylation: Link Between Neuronal Aging and Alzheimer's

Researchers used CRISPR screening to identify neddylation as a vital regulator of neuronal aging. Blocking this pathway in stem cell-derived neurons triggers senescence, DNA damage, and proteostasis failure. These age-related hallmarks drive Tau pathology and cell death.
References:
* Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration
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