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498-Enhancer Landscapes of Microglial Plasticity

18 min•12 februari 2026
PAMs are yolk sac-derived microglia that regulate myelinogenesis. They exhibit plasticity, transitioning from a reactive state to homeostasis, then switching to DAM or WAM states during injury or aging. Epigenomic profiling identifies specific enhancers and TFs like ATF4 as key regulators.
References:
* Hamagami N, Kapadia D, Barclay K M, et al. State-specific enhancer landscapes govern microglial...去小宇宙查看完整单集简介
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