539-CRISPR Screens Reveal Neuronal Tau Proteostasis

This research paper details a large-scale CRISPR screening study conducted in human iPSC-derived neurons to identify genes that regulate tau protein levels and aggregation. The authors discovered that the CUL5-ARIH2 ubiquitin ligase complex plays a critical role in marking tau for degradation, while oxidative stress and mitochondrial dysfunction trigger the formation of a toxic 25-kDa tau fragment...去小宇宙查看完整单集简介
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