581-Histidine Scanning for Engineering TCR Sensitivity

This research introduces histidine scanning as a versatile engineering strategy to improve the signaling strength of T cell receptors and other mechanosensory proteins. By replacing specific residues with histidine, the scientists identified hotspots that promote the formation of catch bonds, which are molecular interactions that strengthen when subjected to physical force. This method allows for ...去小宇宙查看完整单集简介
前往小宇宙评论区与主播互动