590-PHNToM: Inference of Oncogene Mutation Function

Genetic mutations can alter protein behavior in various ways, including gaining new functions (neomorphs), increasing existing activity (hypermorphs), or decreasing physiological effects (hypomorphs). These researchers introduced PHNToM, a computational framework designed to classify variants of unknown functional significance (VUFS) by comparing their regulatory signatures to established mutation...去小宇宙查看完整单集简介
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