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630-CAF Lipid Reprogramming Enhances T Cell Cytotoxicity

20 min•12 mars 2026
The research identifies a novel subset of cancer-associated fibroblasts (CAFs), termed PTGER3+ lipoCAFs, which are induced by chemotherapy in bladder cancer. Unlike typical stromal cells that shield tumors, these fibroblasts undergo metabolic reprogramming to enhance lipid oxidation, specifically using the enzyme CYP1B1 to convert arachidonic acid into the metabolite 11-HETE. This secreted molecul...去小宇宙查看完整单集简介
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