631-Chemotherapy-Induced Tumor Immune Evasion

This research reveals that chemotherapy unintentionally triggers immune evasion in liver metastases by reprogramming resident Kupffer cells into a suppressive LEPR+ state. This transition is driven by tumor cells that, when damaged by treatment, release cGAMP to activate STING-ID1 signaling within the liver’s immune environment. Once differentiated, these LEPR+ Kupffer cells infiltrate the tumor a...去小宇宙查看完整单集简介
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