635-The Medulloblastoma Metastatic Niche

This research explores how metastatic medulloblastoma survives in the nutrient-poor environment of the leptomeninges by actively altering its surroundings. The study reveals that cancer cells release PDGF ligands to recruit meningeal fibroblasts, which are then reprogrammed into a specialized, tumor-supporting state. These modified fibroblasts promote metastatic growth and colonization by signalin...去小宇宙查看完整单集简介
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