670-Evolution of IDH-Mutant Glioma Progression

This research investigates how IDH-mutant gliomas transform from slow-growing tumors into aggressive, fatal malignancies. By comparing single-cell gene expression and chromatin accessibility, the authors found that these tumors start as indolent cells resembling oligodendrocyte progenitors (OPCs) fueled by epigenetic changes like DNA hypermethylation. As the disease progresses, the tumors shift to...去小宇宙查看完整单集简介
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