702-Structural Basis for mTORC2 & Akt Phosphorylation

This research article identifies the structural basis for how the protein kinase mTORC2 selectively recruits and phosphorylates Akt and related AGC family kinases. Researchers utilized expressed protein ligation to create semisynthetic Akt probes, allowing them to trap the transient kinase-substrate interaction for high-resolution cryo-electron microscopy analysis. The study reveals that mTORC2 re...去小宇宙查看完整单集简介
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